Fructose copper microbiome

Song, M., Li, X., Zhang, X., Shi, H., Vos, M. B., Wei, X., Wang, Y., Gao, H., Rouchka, E. C., Yin, X., Zhou, Z., Prough, R. A., Cave, M. C., & McClain, C. J. (2018). Dietary copper-fructose interactions alter gut microbial activity in male rats. American journal of physiology. Gastrointestinal and liver physiology, 314(1), G119–G130.Continue reading “Fructose copper microbiome”


We at CopperOne have been telling customers to add cuprous niacin to an oil to keep it in the +1 oxidation state. Why not olive oil? Oleuropein is “the most important phenolic compound present in olive cultivars. It has a role as a plant metabolite, a radical scavenger, an anti-inflammatory agent, an antineoplastic agent, anContinue reading “Oleuropein”

Copper and feel good hormones

This post is about peptide hormones that make us feel good. It is not about dopamine and serotonin… The copper enzyme Peptidylglycine α-Amidating Monooxygenase (PAM) is responsible for the clipping of peptides to form common hormones we know as vasopressin, oxytocin, α-MSH, and β-endorphin. [1] How PAM works PAM is actually two enzymes in one.Continue reading “Copper and feel good hormones”

Glutathione the Copper Chaperone

This post examines a report from the laboratory of Dr Christopher Fahrni at Georgia Tech University. What this group is saying is that the small molecule glutathione can chaperone intra cellular Cu+ to really low femptomole levels. [1] This is a glutathione molecule. The carboxy C-terminus (had end) is a glycine. A carboxy group isContinue reading “Glutathione the Copper Chaperone”

Western Diet and Wilson’s Disease

Lessons from a Wilson’s Disease mouse model Wilson’s Disease is an affliction of not being to export copper due to mutations in the ATP7B Cu+ transporter.  This study asked the question of how copper in the proper oxidation state affect the health hazards of a high fat Western Diet (WD) versus the normal control (NC)Continue reading “Western Diet and Wilson’s Disease”