This post investigates a claim in a review by Morrel and coworkers that excessive dietary fructose can decrease the expression of Ctr1 in the duodenum. [1] How could this happen? What is transcription factor for Ctr1? As it turns out, both Cu+ and Cu2+ can bind to the CTR1 transcription factor Sp1 and negatively regulateContinue reading “Sp1 and copper”
Author Archives: BL
Copper, fructose, and NAFLD
Fructose is not metabolized like glucose. Its consumption has been linked to fatty liver disease. Adequate copper in the +2 oxidation state was not better than copper deficiency in rats on a high fructose diet.
Copper and aging brain
This review carried the torch of Dr Brewer in trying to shed light on the hazards of using copper (II) sulfate to control pathogens on food crops to the international community. This review cited the literature on links to Alzheimer’s Disease and alternatives to CuSO4 to control pathogens. This review did not discuss whether theContinue reading “Copper and aging brain”
Brain copper transport
Menkes Disease is an X-linked infant onset disorder of copper transport caused by mutations in the ATP7A copper transporter. [1] Seizures, hypotonia, gross motor delays were some of the neurological deficits caused by mutations in ATP7A. The authors of Wikipedia list a series of symptoms of Menkes Disease that rads like a list of everyContinue reading “Brain copper transport”
Protected: In defense of Dr Brewer
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Protected: CHNRA7 in white blood cells
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Protected: Neuro-PASC
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Protected: Extracellular mitochondria
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Protected: Mitochondria in chronically stimulated T cells
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Protected: Mitochondria and T cell exhaustion
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Cuprous niacin 