Uncategorized – Cuprous niacin

AL amyloidosis

We don’t know how, but Cu(II) enhances toxicity of amyloid forming light chains in a C elegans model of heart failure.

Protected: Cuproptosis part 2

There is no excerpt because this is a protected post.

Where this post is going… The featured image says it all. A lipoic acid binding component of the pyruvate dehydrogenase complex, DLAT, binds Cu2+ and causes the oligomerization of the DLAT subunit in such a way as to cause “regulated cell death.” There is a lot of controversy and talk as to which enzyme isContinue reading “Cuproptosis”

Fructose copper microbiome

Song, M., Li, X., Zhang, X., Shi, H., Vos, M. B., Wei, X., Wang, Y., Gao, H., Rouchka, E. C., Yin, X., Zhou, Z., Prough, R. A., Cave, M. C., & McClain, C. J. (2018). Dietary copper-fructose interactions alter gut microbial activity in male rats. American journal of physiology. Gastrointestinal and liver physiology, 314(1), G119–G130.Continue reading “Fructose copper microbiome”

Oleuropein

We at CopperOne have been telling customers to add cuprous niacin to an oil to keep it in the +1 oxidation state. Why not olive oil? Oleuropein is “the most important phenolic compound present in olive cultivars. It has a role as a plant metabolite, a radical scavenger, an anti-inflammatory agent, an antineoplastic agent, anContinue reading “Oleuropein”

Cu(II) reductase

This post addresses the existence of a putative Cu(II) reductase that sits adjacent to the Ctr1 Cu+ channel. Sukru Gulec and James Collins wrote an excellent review on absorption of iron (Fe) and copper (Cu). This is a composite of three images going from the entry of Cu in the duodenum, transfer to the hepatocyte,Continue reading “Cu(II) reductase”

Copper and feel good hormones

This post is about peptide hormones that make us feel good. It is not about dopamine and serotonin… The copper enzyme Peptidylglycine α-Amidating Monooxygenase (PAM) is responsible for the clipping of peptides to form common hormones we know as vasopressin, oxytocin, α-MSH, and β-endorphin. [1] How PAM works PAM is actually two enzymes in one.Continue reading “Copper and feel good hormones”

Copper absorption analogy

Ctr1 is like the entrance of a hotel. We at CopperOne think that any copper in the cuprous, Cu+, oxidation state is best because entering through the specific Ctr1 channel is like entering a hotel through the front door. Once you enter, you have a bell hop and concierge to help you find your wayContinue reading “Copper absorption analogy”

Glutathione the Copper Chaperone

This post examines a report from the laboratory of Dr Christopher Fahrni at Georgia Tech University. What this group is saying is that the small molecule glutathione can chaperone intra cellular Cu+ to really low femptomole levels. [1] This is a glutathione molecule. The carboxy C-terminus (had end) is a glycine. A carboxy group isContinue reading “Glutathione the Copper Chaperone”

Copper and heart disease

Copper deficiency is associated with heart disease. This is a journey through the literature as to which copper enzymes are important.