fatty liver disease

NAFLD and copper deficiency

For you cooks out there, have you ever been cooking a pot of something and and added a second ingredient to compensate for the first? Soon the second ingredient becomes too much and needs to be dealt with. The Harder 2022 study started with the premise that hepatic copper is regulated by fat accumulation. ItContinue reading “NAFLD and copper deficiency”

Fructose copper microbiome

These authors started with the knowledge that too little and perhaps too much copper can lead to non-alcoholic fatty liver diseae (NAFLD). Fructose was also considered a contributor to NAFLD. What we at CopperOne think is really cool is that these investigators also looked at the intestinal bacteria.

Western Diet and Wilson’s Disease

Wilson’s Disease is an affliction of not being to export copper due to mutations in the ATP7B Cu+ transporter. This study asked the question of how copper in the proper oxidation state affect the health hazards of a high fat Western Diet (WD) versus the normal control (NC) diet. This study utilized wild type mice and those same C57BL/6 mice with the ATP7B gene knocked out (ko)

Copper, fructose, and NAFLD

Fructose is not metabolized like glucose. Its consumption has been linked to fatty liver disease. Adequate copper in the +2 oxidation state was not better than copper deficiency in rats on a high fructose diet.

FattyLiver in Cows

Some of the information in the post may be new to the average dairy farmer. Our featured image, adapted from sirtuins for human health, is a good introduction to what this post is about. The dairy farmer may have heard that drinking resveratrol rich red wine is a good way to get the same benefits of caloric restriction as they both activate the longevity enzyme called sirtuin 1, or Sirt1 for short. Why is negative energy balance so bad for cows? Maybe it is not so bad if the cow has the right nutrition. We will argue that the rumen protected niacin and copper supplements you’ve been giving your cows have some interesting science behind them.

This post describes an Egyptian study with cuprous nicotinic acid showing amelioration of fatty liver disease in a rat model.